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CPDM's Collection of Hematologic PDX Models

  • CPDM has one of the largest collections of hematologic cancer PDX models of diverse subtypes. These PDX models were first published in Cancer Cell. 2016 and subsequently appeared in many studies. This model collection was previously distributed under the Public Repository of Xenografts (PRoXe) by David Weinstock, MD, of Dana-Farber.

    See our detailed model lists for more information about our hematologic models. RNA-seq data, whole-exome seq data, and low-pass WGS data are available on cBioPortal. HLA data inferred from RNA-seq data is also available here. Industry users, please refer to Column G in the hematologic models list for distribution permissions.

    Learn more about ordering and licensing these models, or email us at models@dfci.harvard.edu to submit an inquiry.

    See CPDM's SOPs for working with these models for guidance.


  • Summarized Diagnosis # of Models
    Acute Lymphocytic Leukemia 152
    Acute Myeloid Leukemia 69
    Mature B-Cell Neoplasms 31
    Mature T- And NK-Cell Neoplasms 16
    Acute Leukemia Of Ambiguous Lineage 3
    Myelodysplastic Syndrome 2

    Some of these PDX models have been transduced with the mCLP chemiluminescent marker. Please see the table below.

    Model ID Chemiluminescent Marker Diagnosis
    DFBL-20954 mCLP Double-Hit Non-Hodgkin's Lymphoma
    DFBL-69487 mCLP Double-Hit Non-Hodgkin's Lymphoma
    DFBL-39435 mCLP Mantle Cell Lymphoma
    DFBL-69579 mCLP Adult T-Cell Leukemia/Lymphoma
    DFBL-45197 mCLP Follicular Lymphoma