CPDM's Collection of Hematologic PDX Models

CPDM has one of the largest collections of hematologic cancer PDX models of diverse subtypes. These PDX models were first published in Cancer Cell 2016 and subsequently appeared in many studies. This model collection was previously distributed under the Public Repository of Xenografts (PRoXe) by David Weinstock, MD, formerly of Dana-Farber.

See our detailed model lists for more information about our hematologic models. RNA-seq data, whole-exome seq data, and low-pass WGS data are available on cBioPortal. HLA data inferred from RNA-seq data is also available here. Industry users, please refer to Column G in the hematologic models list for distribution permissions.

Learn more about ordering and licensing these models, or email us at models@dfci.harvard.edu to submit an inquiry.

See CPDM's SOPs for working with these models for guidance.

Summarized Diagnosis # of Models
Acute Lymphocytic Leukemia 152
Acute Myeloid Leukemia 69
Mature B-Cell Neoplasms 31
Mature T- And NK-Cell Neoplasms 16
Acute Leukemia Of Ambiguous Lineage 3
Myelodysplastic Syndrome 2

Some of these PDX models have been transduced with the mCLP chemiluminescent marker. Please see the table below.

Model ID Chemiluminescent Marker Diagnosis
DFBL-20954 mCLP Double-Hit Non-Hodgkin's Lymphoma
DFBL-69487 mCLP Double-Hit Non-Hodgkin's Lymphoma
DFBL-39435 mCLP Mantle Cell Lymphoma
DFBL-69579 mCLP Adult T-Cell Leukemia/Lymphoma
DFBL-45197 mCLP Follicular Lymphoma