The Center for Neuro-Oncology is at the forefront of discovery and development of new treatments for brain and central nervous system tumors. Center investigators have made important inroads in basic and clinical research to better understand the biology
that underlies these tumors and identify and test new therapies.
Our researchers are also involved in many projects for the Dana-Farber/Harvard Cancer Center Brain Cancer SPORE (Specialized Program of Research Excellence), including those focused on PI3K inhibitors, IDH mutations, Olig2 suppressors and immunotherapy.
Clinical Trials
Our Center offers a number of exciting clinical trials for patients with primary and metastatic brain and spinal cord tumors. These trials explore several innovative approaches to improve outcomes and quality of life for brain tumor patients, including
immunotherapy, targeted therapies, and anti-angiogenesis inhibitors.
Learn more about our clinical trials.
Research Areas
Our research team is leading basic, translational and clinical research aimed at advancing the understanding, diagnosis, and treatment of brain tumors. Areas of focus include:
In addition, we are conducting research on CNS and systemic lymphoma, brain metastasis, adaptive designs for brain tumor clinical trials, neurologic complications of cancer, oncolytic viruses, surgical brain mapping, molecular and cellular surgical
oncology, CNS drug delivery/mass spectrometry, preclinical animal models, tumor metabolism/IDH mutations, Olig 2 suppression, and advanced neuro-imaging.
Our Physician-Researchers
Patrick Wen, MD
Focus:
Targeted therapies
Pub Med
David Reardon, MD
Focus:
Immunotherapy
Pub Med
Ennio Chiocca, MD, PhD
Focus: Novel experimental therapies for malignant brain tumors
Chiocca Lab
Pub Med
Brian Alexander, MD, MPH
Pub Med
Nathalie Agar, PhD
Focus: Molecular diagnosis and prognosis for clinical and surgical applications
Surgical Molecular Imaging Lab
Pub Med
Rameen Beroukhim, MD, PhD
Pub Med
Alexandra Golby, MD
Focus: Structural and functional MRI and brain electrophysiology
Surgical Brain Mapping Lab
Pub Med
Raymond Huang, MD, PhD
Focus: Advanced neuro-imaging
Pub Med
William Kaelin, Jr., MD
Focus:
Targeted therapies and precision cancer medicine
Kaelin Lab
Pub Med
Eudocia Lee, MD, MPH
Pub Med
Keith Ligon, MD, PhD
Focus:
Genotyping and neuropathology
Ligon Lab
Pub Med
Srinivasan Mukundan, Jr. MD, PhD
Focus: Advanced neuro-imaging
Pub Med
Thomas Roberts, PhD
Focus:
Targeted therapies and precision cancer medicine
Pub Med
Sandro Santagata, MD, PhD
Focus: Neuro-pathology
Pub Med
Charles Stiles, PhD
Focus: Olig-2 suppression
Pub Med
Read our Insight blog for information and inspiration about Dana-Farber brain tumor research.