Patrick Y. Wen, MD

Patrick Y. Wen, MD

Neuro-oncology

Contact Information

Office Phone Number

617-632-2166

Fax

617-632-4773

Biography

Patrick Y. Wen, MD

Dr. Wen graduated from the Medical College of St. Bartholomew's Hospital, University of London, in 1981. He completed his internal medicine training at the University of London postgraduate hospitals and his neurology residency in the Harvard-Longwood Neurology Training Program. . He is a former President of the Society For Neuro-Oncology, Editor-In-Chief of Neuro-Oncology and Principal Investigator of the Adult Brain Tumor Consortium. He is currently co-chair of the National Cancer Institute Brain Malignancy Steering Committee.  His research is focused on novel therapies for brain tumors, especially gliomas, as well as improving clinical trial design and response assessment.

View Dr Wen's Research

Novel Therapies For Adult Brain Tumors

The primary goal of our multidisciplinary group of investigators is to find more effective treatments for patients with brain tumors. Our program is especially interested in the development of novel targeted molecular therapies and immunotherapies. We have a large number of clinical trials of these agents in progress. The majority of these studies are focused on glioblastomas and and IDH mutated gliomas, but there are also trials for CNS lymphoma, meningiomas, brain metastases and leptomeningeal metastases. Our group contributed to the FDA approval of bevacizumab (avastin) for glioblastomas, dabrafenib and trametinib for BRAFv600E mutated gliomas, among other cancers, and vorasidenib for IDH mutated low grade gliomas.

Another major focus of our research is to improve response assessment, clinical trial endpoints and design to accelerate the evaluation of novel therapies for brain tumor patients. Dr Wen is a member of the Response Assessment in Neuro-Oncology (RANO) Steering Committee that developed the response assessments used in most brain tumors clinical trials. He and his colleagues are conducting the INdividualized Screening trial of Innovative Glioblastoma Therapy (INSIGhT) trial, a platform trial using Bayesian adaptive design to rapidly evaluate multiple therapies for glioblastoma. He also co-chairs the Agents Selection Committee of GBM AGILE, an international platform trial that also uses Bayesian randomization to evaluate therapies for glioblastoma.

 

Researcher

Physician

Director, Center for Neuro-Oncology
Institute Physician
Professor of Neurology, Harvard Medical School

Centers/Programs

CNS Lymphoma Center

Clinical Interests

Brain and leptomeningeal metastases, Neurologic complications in cancer patients, Paraneoplastic syndromes, Primary brain and spinal cord tumors including gliomas, glioblastoma, primary CNS lymphoma, and ependymoma

Board Certification

  • Neurology, 1989
  • Neuro-Oncology

Fellowship

  • Harvard Medical School, Neurology

Residency

  • Harvard-Longwood Neurology Training Program, Neurology
  • University of London, Internal Medicine

Medical School

  • University of London

Research

    Novel Therapies For Adult Brain Tumors

    The primary goal of our multidisciplinary group of investigators is to find more effective treatments for patients with brain tumors. Our program is especially interested in the development of novel targeted molecular therapies. We currently have a large number of clinical trials of these agents in progress. Recently we also started trials of combinations of targeted molecular agents, which are likely to be more effective than treatment with single agents alone. As part of these trials, we are also genotyping the tumors and correlating them with response to treatment in the hope of identifying subgroups of patients who are particularly likely to benefit. In addition, we are conducting clinical trials evaluating novel inhibitors of angiogenesis, chemotherapy combinations, intratumoral agents delivered by convection, and tumor vaccines. A second focus of our program is the development of novel therapies for meningiomas, brain metastases, and leptomeningeal metastases; clinical studies evaluating targeted molecular agents and novel chemotherapeutic agents against these cancers are under way. We also collaborate with colleagues in Pediatric Neuro-Oncology and the Department of Cancer Biology in a preclinical program directed at identifying novel targets for therapy and evaluating new agents for clinical trials.In addition, our program has a strong interest in quality-of-life issues affecting patients with brain tumors, in particular, venous thromboembolic disease. We are currently studying the molecular basis of venous thromboembolism and evaluating the benefit of prophylactic anticoagulation. Furthermore, we are about to begin studies evaluating the role of prophylactic anticonvulsants in patients with malignant glioma who have not had seizures and medications such as methylphenidate for radiation-induced fatigue.

    Publications

      • Tumors of the Spinal Cord. Neurology: Basic and Clinical Neurosciences. 2050. View in: Pubmed

      • Neurological Complications of Oncological therapy. Turner CD, Goldman S, editors. Late Effects of Treatment for Brain Tumors. 2050. View in: Pubmed

      • Inhibiting Angiogenesis in Malignant Gliomas. Griswold W, Soffieti R, editors. handbook of Clinical Neurology: Neuro-Oncology. 2050. View in: Pubmed

      • CNS toxicities from cancer therapy. Neurologic Clinics. 2050. View in: Pubmed

      • Brain Tumors in Adults. Neurologic Clinics. 2050. View in: Pubmed

      • Neurologic complications of Bone Marrow Transplantation. Schiff D, Kesari S, Wen PY, editors. Cancer Neurology in Clinical Practice. 2050. View in: Pubmed

      • Targeted Molecular Therapies for Meningiomas. Nurosurg Focus. 2050. View in: Pubmed

      • Therapy for Peritumoral Edema in High Grade Gliomas. Rivista Medica. 2050. View in: Pubmed

      • Cancer Neurology. Samuels MA, editor. Neurology for the Practicing Physician. 2050. View in: Pubmed

      • Antiangiogenic Therapy for malignant Gliomas. Expert Rev in AntiCancer Therapy. 2050. View in: Pubmed

      • Neurologic Complications of Chemotherapy. Schiff D, Kesari S, Wen PY, editors. Cancer Neurology in Clinical Practice. 2050. View in: Pubmed

      • Neurological Complications of Oncology Therapy. Newton h, Jolesz F, editors. Handbook fo neuro-Oncology Neuro-Imaging. 2050. View in: Pubmed

      • Nervous System Metastases. Bradley W, daroff R, Fenichel G, Jankovic J, editors. Neurology in Clinical Practice. 2050. View in: Pubmed

      • Neurologic complications of chemotherpay. Newton H, Malkin M, editors. Neurologic complications of systemic cancer and antineoplastic therapy. 2050. View in: Pubmed

      • Neurologic Complications of Prostate Cancer. Kantoff PW, Carroll P, D'Amico A, editors. Prostate Cancer. 2050. View in: Pubmed

      • Cancer Neurology in Clinical Practice. 2050. View in: Pubmed

      • Novel Therapies in Brain Tumors. Neurol Clin. 2050. View in: Pubmed

      • Targeted radionuclide therapy for gliomas: emerging clinical trial landscape. Neuro Oncol. 2024 Aug 06. View in: Pubmed

      • DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology. Neuro Oncol. 2024 Aug 05; 26(8):1367-1387. View in: Pubmed

      • Evaluating the Base Excision Repair Inhibitor TRC102 and Temozolomide for Patients with Recurrent Glioblastoma in the Phase 2 Adult Brain Tumor Consortium Trial BERT. Clin Cancer Res. 2024 Aug 01; 30(15):3167-3178. View in: Pubmed

      • A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients. Neuro Oncol. 2024 Jul 31. View in: Pubmed

      • SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors. Neuro Oncol. 2024 Jul 29. View in: Pubmed

      • RANO 2.0 criteria: concepts applicable to the neuroradiologist's clinical practice. Curr Opin Oncol. 2024 Jul 05. View in: Pubmed

      • Challenges, limitations, and pitfalls of PET and advanced MRI in patients with brain tumors: A report of the PET/RANO group. Neuro Oncol. 2024 Jul 05; 26(7):1181-1194. View in: Pubmed

      • A multicenter, phase 1, Adult Brain Tumor Consortium trial of oral terameprocol for patients with recurrent high-grade glioma (GATOR). Cell Rep Med. 2024 Jul 16; 5(7):101630. View in: Pubmed

      • A Neuroradiologist's Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults. AJNR Am J Neuroradiol. 2024 Jun 28. View in: Pubmed

      • The biological significance of tumor grade, age, enhancement and extent of resection in IDH mutant gliomas: how should they inform treatment decision in the era of IDH inhibitors? Invited review. Neuro Oncol. 2024 Jun 24. View in: Pubmed

      • Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions. Neuro Oncol. 2024 Jun 21. View in: Pubmed

      • Cavitation monitoring, treatment strategy, and acoustic simulations of focused ultrasound blood-brain barrier disruption in patients with glioblastoma. J Control Release. 2024 Aug; 372:194-208. View in: Pubmed

      • Joint EANM/EANO/RANO/SNMMI practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor ligands: version 1.0. Eur J Nucl Med Mol Imaging. 2024 Jun 20. View in: Pubmed

      • NRG-BN002: Phase I Study of Ipilimumab, Nivolumab, and the Combination in Patients with Newly Diagnosed GBM. Neuro Oncol. 2024 Jun 14. View in: Pubmed

      • Effect of ursodeoxycholic acid on preventing SARS-CoV-2 infection in patients with liver transplantation: a multicenter retrospective cohort study. QJM. 2024 Jun 04; 117(5):339-347. View in: Pubmed

      • Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review. Neuro Oncol. 2024 Jun 03; 26(6):993-1011. View in: Pubmed

      • Non-invasive Blood-Brain Barrier Disruption using Acoustic Holography with a Clinical Focused Ultrasound System. IEEE Trans Biomed Eng. 2024 May 30; PP. View in: Pubmed

      • Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors. Commun Med (Lond). 2024 May 21; 4(1):95. View in: Pubmed

      • Glioma. Nat Rev Dis Primers. 2024 May 09; 10(1):33. View in: Pubmed

      • Radioligand therapies in meningioma - evidence and future directions. Neuro Oncol. 2024 May 04. View in: Pubmed

      • ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma. Neuro Oncol. 2024 May 03; 26(Supplement_2):S173-S181. View in: Pubmed

      • Selective DRD2 antagonist and ClpP agonist ONC201 in a recurrent non-midline H3 K27M-mutant glioma cohort. Neuro Oncol. 2024 May 03; 26(Supplement_2):S165-S172. View in: Pubmed

      • Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance. Neuro Oncol. 2024 May 03; 26(5):965-974. View in: Pubmed

      • Meningioma: International Consortium on Meningiomas (ICOM) consensus review on scientific advances & treatment paradigms for clinicians, researchers, and patients. Neuro Oncol. 2024 May 02. View in: Pubmed

      • Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma. medRxiv. 2024 Apr 18. View in: Pubmed

      • Defining interventions and metrics to improve diversity in CNS clinical trial participation: A SNO and RANO effort. Neuro Oncol. 2024 04 05; 26(4):596-608. View in: Pubmed

      • Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma. Cancer Cell. 2024 May 13; 42(5):904-914.e9. View in: Pubmed

      • Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma. Clin Cancer Res. 2024 Apr 01; 30(7):1327-1337. View in: Pubmed

      • Systematic characterization of antibody-drug conjugate targets in central nervous system tumors. Neuro Oncol. 2024 03 04; 26(3):458-472. View in: Pubmed

      • Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping. Nat Med. 2024 Mar; 30(3):907. View in: Pubmed

      • ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma. J Clin Oncol. 2024 May 01; 42(13):1542-1552. View in: Pubmed

      • [Polycystic ovary syndrome is positively correlated with periodontitis: a prospective study]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Jan 20; 44(1):36-44. View in: Pubmed

      • Adult neuro-oncology trials in the United States over 5 decades: Analysis of trials completion rate to guide the path forward. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdad169. View in: Pubmed

      • RANO 2.0: The revised Response Assessment in Neuro-Oncology (RANO) criteria for high- and low-grade glial tumors in adults designed for the future. Neuro Oncol. 2024 01 05; 26(1):2-4. View in: Pubmed

      • Brain tumor-related epilepsy management: A Society for Neuro-oncology (SNO) consensus review on current management. Neuro Oncol. 2024 01 05; 26(1):7-24. View in: Pubmed

      • Updated Response Assessment in Neuro-Oncology (RANO) for Gliomas. Curr Neurol Neurosci Rep. 2024 02; 24(2):17-25. View in: Pubmed

      • PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): a report of the RANO group. Lancet Oncol. 2024 Jan; 25(1):e29-e41. View in: Pubmed

      • Author Correction: Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial. Nat Med. 2024 Jan; 30(1):302. View in: Pubmed

      • Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration. Front Radiol. 2023; 3:1267615. View in: Pubmed

      • Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma. Neuro Oncol. 2023 12 08; 25(12):2165-2176. View in: Pubmed

      • Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma. J Clin Oncol. 2023 11 10; 41(32):4945-4952. View in: Pubmed

      • Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discov. 2023 11 01; 13(11):2370-2393. View in: Pubmed

      • Re-irradiation of recurrent IDH-wildtype glioblastoma in the bevacizumab and immunotherapy era: Target delineation, outcomes and patterns of recurrence. Clin Transl Radiat Oncol. 2024 Jan; 44:100697. View in: Pubmed

      • Liquid biopsy epigenomic profiling for cancer subtyping. Nat Med. 2023 Nov; 29(11):2737-2741. View in: Pubmed

      • Activity of a first-in-class oral HIF2-alpha inhibitor, PT2385, in patients with first recurrence of glioblastoma. J Neurooncol. 2023 Oct; 165(1):101-112. View in: Pubmed

      • Clinical trial links oncolytic immunoactivation to survival in glioblastoma. Nature. 2023 Nov; 623(7985):157-166. View in: Pubmed

      • Depth of Radiographic Response and Time to Tumor Regrowth Predicts Overall Survival Following Anti-VEGF Therapy in Recurrent Glioblastoma. Clin Cancer Res. 2023 10 13; 29(20):4186-4195. View in: Pubmed

      • Molecular Profiling and Targeted Therapies in Gliomas. Curr Neurol Neurosci Rep. 2023 10; 23(10):627-636. View in: Pubmed

      • Advanced molecular diagnostic tools: A step closer to precision medicine in neuro-oncology. Neuro Oncol. 2023 10 03; 25(10):1750-1751. View in: Pubmed

      • A genomic score to predict local control among patients with brain metastases managed with radiation. Neuro Oncol. 2023 10 03; 25(10):1815-1827. View in: Pubmed

      • Correcting the drug development paradigm for glioblastoma requires serial tissue sampling. Nat Med. 2023 Oct; 29(10):2402-2405. View in: Pubmed

      • RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults. J Clin Oncol. 2023 Nov 20; 41(33):5187-5199. View in: Pubmed

      • Novel trial designs in neuro-oncology. Curr Opin Neurol. 2023 12 01; 36(6):571-578. View in: Pubmed

      • Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. J Clin Oncol. 2023 Dec 20; 41(36):5524-5535. View in: Pubmed

      • Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas. Sci Transl Med. 2023 09 06; 15(712):eadi0069. View in: Pubmed

      • Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy. bioRxiv. 2023 Aug 28. View in: Pubmed

      • Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients. Clin Cancer Res. 2023 Aug 15; 29(16):3017-3025. View in: Pubmed

      • Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival. Acta Neuropathol. 2023 10; 146(4):647-649. View in: Pubmed

      • Reply to Di Nunno et al. concerning objective response rates targets for recurrent glioblastoma clinical trials: Toward surrogate endpoints for phase II trials in patients with recurrent glioblastoma. Neuro Oncol. 2023 08 03; 25(8):1548-1549. View in: Pubmed

      • ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma. Clin Cancer Res. 2023 07 14; 29(14):2651-2667. View in: Pubmed

      • Evaluating hematologic parameters in newly diagnosed and recurrent glioblastoma: Prognostic utility and clinical trial implications of myelosuppression. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad083. View in: Pubmed

      • Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults. Neuro Oncol. 2023 07 06; 25(7):1200-1224. View in: Pubmed

      • Telomerase inhibition is an effective therapeutic strategy in TERT promoter-mutant glioblastoma models with low tumor volume. Neuro Oncol. 2023 07 06; 25(7):1275-1285. View in: Pubmed

      • Accessible Data Collections for Improved Decision Making in Neuro-Oncology Clinical Trials. Clin Cancer Res. 2023 06 13; 29(12):2194-2198. View in: Pubmed

      • Understanding the patient experience and treatment benefits in patients with non-small-cell lung cancer with brain metastasis. Cancer Med. 2023 06; 12(12):13637-13648. View in: Pubmed

      • Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. N Engl J Med. 2023 Aug 17; 389(7):589-601. View in: Pubmed

      • Pembrolizumab in brain metastases of diverse histologies: phase 2 trial results. Nat Med. 2023 07; 29(7):1728-1737. View in: Pubmed

      • Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival. Neuro Oncol. 2023 06 02; 25(6):1017-1028. View in: Pubmed

      • Phase I study of a novel glioblastoma radiation therapy schedule exploiting cell-state plasticity. Neuro Oncol. 2023 06 02; 25(6):1100-1112. View in: Pubmed

      • Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders' Collaborative Consortium (EORTC 1419). Eur J Cancer. 2023 08; 189:112913. View in: Pubmed

      • EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection. Neuro Oncol. 2023 05 04; 25(5):813-826. View in: Pubmed

      • Incidence proportion and prognosis of leptomeningeal disease among patients with breast vs. non-breast primaries. Neuro Oncol. 2023 05 04; 25(5):973-983. View in: Pubmed

      • Molecular Profiling in Neuro-Oncology: Where We Are, Where We're Heading, and How We Ensure Everyone Can Come Along. Am Soc Clin Oncol Educ Book. 2023 May; 43:e389322. View in: Pubmed

      • An expanded role for surgery in grade 3 1p/19q co-deleted oligodendroglioma. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad046. View in: Pubmed

      • Understanding the activity of antibody-drug conjugates in primary and secondary brain tumours. Nat Rev Clin Oncol. 2023 06; 20(6):372-389. View in: Pubmed

      • Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial. Nat Med. 2023 05; 29(5):1103-1112. View in: Pubmed

      • Evaluation of Standard Response Assessment in Neuro-Oncology, Modified Response Assessment in Neuro-Oncology, and Immunotherapy Response Assessment in Neuro-Oncology in Newly Diagnosed and Recurrent Glioblastoma. J Clin Oncol. 2023 06 10; 41(17):3160-3171. View in: Pubmed

      • National-level overall survival patterns for molecularly-defined diffuse glioma types in the United States. Neuro Oncol. 2023 04 06; 25(4):799-807. View in: Pubmed

      • Current drug development and trial designs in neuro-oncology: report from the first American Society of Clinical Oncology and Society for Neuro-Oncology Clinical Trials Conference. Lancet Oncol. 2023 04; 24(4):e161-e171. View in: Pubmed

      • Artificial intelligence (AI)-based decision support improves reproducibility of tumor response assessment in neuro-oncology: An international multi-reader study. Neuro Oncol. 2023 03 14; 25(3):533-543. View in: Pubmed

      • Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial. Nat Med. 2023 03; 29(3):615-622. View in: Pubmed

      • Validation of Predictive Analyses for Interim Decisions in Clinical Trials. JCO Precis Oncol. 2023 02; 7:e2200606. View in: Pubmed

      • The Blood-Brain Barrier: Implications for Experimental Cancer Therapeutics. Annu Rev Cancer Biol. 2023 Apr; 7:265-289. View in: Pubmed

      • Negative trials over and over again: How can we do better? Neuro Oncol. 2023 01 05; 25(1):1-3. View in: Pubmed

      • Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro Oncol. 2023 01 05; 25(1):4-25. View in: Pubmed

      • NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022. J Natl Compr Canc Netw. 2023 01; 21(1):12-20. View in: Pubmed

      • Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy. Ann Oncol. 2023 03; 34(3):300-314. View in: Pubmed

      • EANO - EURACAN - SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors. Neuro Oncol. 2022 12 01; 24(12):2015-2034. View in: Pubmed

      • Improved survival among females and association with lymphopenia in patients with newly diagnosed glioblastoma. Neuro Oncol. 2022 11 02; 24(11):2005-2007. View in: Pubmed

      • Investigational PET tracers in neuro-oncology-What's on the horizon? A report of the PET/RANO group. Neuro Oncol. 2022 11 02; 24(11):1815-1826. View in: Pubmed

      • Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions. Neuro Oncol. 2022 10 03; 24(10):1613-1646. View in: Pubmed

      • Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: A joint EORTC BTG and RANO effort. Neuro Oncol. 2022 10 03; 24(10):1726-1735. View in: Pubmed

      • The design and evaluation of hybrid controlled trials that leverage external data and randomization. Nat Commun. 2022 10 02; 13(1):5783. View in: Pubmed

      • World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas: A Review. JAMA Oncol. 2022 10 01; 8(10):1493-1501. View in: Pubmed

      • Therapeutic Advances in Neuro-Oncology. Neurotherapeutics. 2022 10; 19(6):1689-1690. View in: Pubmed

      • Current therapeutic options for glioblastoma and future perspectives. Expert Opin Pharmacother. 2022 Oct; 23(14):1629-1640. View in: Pubmed

      • The predictive value of partial MGMT promoter methylation for IDH-wild-type glioblastoma patients. Neurooncol Pract. 2023 Apr; 10(2):126-131. View in: Pubmed

      • Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma. NPJ Precis Oncol. 2022 Sep 02; 6(1):61. View in: Pubmed

      • Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities. Pigment Cell Melanoma Res. 2022 11; 35(6):554-572. View in: Pubmed

      • A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac123. View in: Pubmed

      • Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma. Nat Commun. 2022 08 16; 13(1):4814. View in: Pubmed

      • Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors. Neuro Oncol. 2022 08 01; 24(8):1219-1229. View in: Pubmed

      • Surveillance imaging frequency in adult patients with lower-grade (WHO Grade 2 and 3) gliomas. Neuro Oncol. 2022 07 01; 24(7):1035-1047. View in: Pubmed

      • Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. View in: Pubmed

      • Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours. Nat Rev Neurol. 2022 09; 18(9):515-529. View in: Pubmed

      • Circulating Immune Cell and Outcome Analysis from the Phase II Study of PD-L1 Blockade with Durvalumab for Newly Diagnosed and Recurrent Glioblastoma. Clin Cancer Res. 2022 06 13; 28(12):2567-2578. View in: Pubmed

      • ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients with ALK-Positive Non-Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges. Clin Cancer Res. 2022 06 13; 28(12):2506-2516. View in: Pubmed

      • Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study. Clin Cancer Res. 2022 06 01; 28(11):2270-2277. View in: Pubmed

      • Liquid biopsy in gliomas: A RANO review and proposals for clinical applications. Neuro Oncol. 2022 06 01; 24(6):855-871. View in: Pubmed

      • Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963. View in: Pubmed

      • Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib. Neuro Oncol. 2022 05 04; 24(5):770-778. View in: Pubmed

      • A molecularly integrated grade for meningioma. Neuro Oncol. 2022 05 04; 24(5):796-808. View in: Pubmed

      • Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients. J Neurooncol. 2022 May; 158(1):111-116. View in: Pubmed

      • DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis. J Neurooncol. 2022 May; 157(3):499-510. View in: Pubmed

      • Phase I/randomized phase II trial of TRC105 plus bevacizumab versus bevacizumab in recurrent glioblastoma: North Central Cancer Treatment Group N1174 (Alliance). Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac041. View in: Pubmed

      • EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults. Neuro Oncol. 2022 04 01; 24(4):516-527. View in: Pubmed

      • Predictors of long-term survival among patients with brain metastases. Neuro Oncol. 2022 03 12; 24(3):494-496. View in: Pubmed

      • Incidence and Predictors of Neurologic Death in Patients with Brain Metastases. World Neurosurg. 2022 06; 162:e401-e415. View in: Pubmed

      • ROAR trial: which treatment is effective after progression? - Authors' reply. Lancet Oncol. 2022 03; 23(3):e94. View in: Pubmed

      • Congress of Neurological Surgeons systematic review and evidence-based guidelines update on the role of cytotoxic chemotherapy and other cytotoxic therapies in the management of progressive glioblastoma in adults. J Neurooncol. 2022 Jun; 158(2):225-253. View in: Pubmed

      • Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma. Clin Cancer Res. 2022 02 15; 28(4):585-593. View in: Pubmed

      • Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement. Clin Cancer Res. 2022 02 15; 28(4):594-602. View in: Pubmed

      • Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. Lancet Oncol. 2022 02; 23(2):e62-e74. View in: Pubmed

      • Deep learning-based automatic tumor burden assessment of pediatric high-grade gliomas, medulloblastomas, and other leptomeningeal seeding tumors. Neuro Oncol. 2022 02 01; 24(2):289-299. View in: Pubmed

      • The use of external control data for predictions and futility interim analyses in clinical trials. Neuro Oncol. 2022 02 01; 24(2):247-256. View in: Pubmed

      • Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study. Ann Oncol. 2022 04; 33(4):406-415. View in: Pubmed

      • Multimodal platform for assessing drug distribution and response in clinical trials. Neuro Oncol. 2022 01 05; 24(1):64-77. View in: Pubmed

      • Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. View in: Pubmed

      • Global Burden and Inequality of Dental Caries, 1990 to 2019. J Dent Res. 2022 04; 101(4):392-399. View in: Pubmed

      • Corrigendum to: Deep learning-based automatic tumor burden assessment of pediatric high-grade gliomas, medulloblastomas, and other leptomeningeal seeding tumors. Neuro Oncol. 2021 Dec 01; 23(12):2124. View in: Pubmed

      • Telomerase as a therapeutic target in glioblastoma. Neuro Oncol. 2021 12 01; 23(12):2004-2013. View in: Pubmed

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