Bruce M. Spiegelman, PhD

Bruce M. Spiegelman, PhD

Researcher

Contact Information

Office Phone Number

(617) 632-3567

Fax

(617) 632-4655

Appointments

(617) 632-3567

Biography

Bruce M. Spiegelman, PhD

Dr. Spiegelman received his PhD in biochemistry from Princeton University in 1978, and completed postdoctoral work at Massachusetts Institute of Technology. In 1982, he joined DFCI and was promoted to professor in 1991. His research focuses on cell differentiation, cellular metabolism, and genetic factors involved in obesity and diabetes.

Researcher

Physician

Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Harvard Medical School

Recent Awards

  • Heinrich Wieland Prize in Lipid Metabolism, University of Munich 1997
  • MERIT Award, NIH 1997
  • National Academy of Sciences 2002
  • American Academy of Arts and Sciences 2002
  • Berson Award, American Physiology Society 2002

Research

    Differentiation of Human Tumors

    Our laboratory focuses on the regulation of energy homeostasis in mammals, primarily at the level of gene transcription. Our studies - which explore the problems of fat cell development, control of metabolic rates, and the pathways of glucose and lipid metabolism - have applications to the development of new therapies for diabetes, obesity, and muscular diseases.Regulation of fat cell differentiation.In 1994, our group identified the master regulator of fat development: peroxisome proliferator-activated receptor gamma (PPAR-gamma), a nuclear receptor. Since then, a major focus of our group has been to understand the pathways that control PPAR-gamma function, its ligands and coactivators, as well as other transcription factors that modify its function. Since synthetic ligands to PPAR-gamma are used clinically as antidiabetic drugs, we are using biochemical approaches to understand the identity of endogenous ligands that control this receptor in vivo. Recently, we have begun to explore the transcriptional control of brown fat differentiation. Since brown fat cells dissipate energy as heat, this feature may provide a potential avenue into the problem of obesity and diabetes.Metabolic control through the PGC-1 coactivators. Biological control via gene transcription was thought to occur mainly through changes in amounts or activities of transcription factors. However, PPAR-gamma and its coactivators (PGC-1) have illustrated that the regulation of critical metabolic programs is controlled largely via transcriptional coactivation. Brown fat-mediated thermogenesis and hepatic gluconeogenesis are both induced through expression of PGC-1 alpha, which then docks on a variety of transcription factor targets. Most recently, we have shown that PGC-1 beta is induced in liver by diets high in saturated and trans fats, and that this coactivator is largely responsible for the subsequent elevation in blood cholesterol and triglyceride synthesis. Current projects center on how the PGC-1 coactivators function mechanically by recruiting chromatin-modifying enzymes. We are also exploring the genetic role of the PGC-1 coactivators in a variety of metabolic states, including obesity, diabetes, muscle wasting, and nerve degeneration. We are particularly interested in how the PGC-1 coactivators control a variety of mitochondrial processes, including oxidative phosphorylation and the detoxification of reactive oxygen species (ROS), which are endogenous agents involved in aging and cancer, a very important area of future research.

    Research Departments

    Publications

      • Irisin reduces amyloid-ß by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling. Neuron. 2023 Aug 30. View in: Pubmed

      • REPTOR and CREBRF encode key regulators of muscle energy metabolism. Nat Commun. 2023 08 15; 14(1):4943. View in: Pubmed

      • Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90a. Mol Cell. 2023 06 01; 83(11):1903-1920.e12. View in: Pubmed

      • Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell Metab. 2023 03 07; 35(3):535-549.e7. View in: Pubmed

      • RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1a. bioRxiv. 2023 Jan 07. View in: Pubmed

      • Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell. 2022 11 23; 185(24):4654-4673.e28. View in: Pubmed

      • Amelioration of pathologic a-synuclein-induced Parkinson's disease by irisin. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2204835119. View in: Pubmed

      • SnapShot: Regulation and biology of PGC-1a. Cell. 2022 04 14; 185(8):1444-1444.e1. View in: Pubmed

      • Measurement of Futile Creatine Cycling Using Respirometry. Methods Mol Biol. 2022; 2448:141-153. View in: Pubmed

      • Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell Metab. 2022 01 04; 34(1):140-157.e8. View in: Pubmed

      • Author Correction: Exercise hormone irisin is a critical regulator of cognitive function. Nat Metab. 2021 Oct; 3(10):1432. View in: Pubmed

      • Exercise hormone irisin is a critical regulator of cognitive function. Nat Metab. 2021 08; 3(8):1058-1070. View in: Pubmed

      • Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metab. 2021 09 07; 33(9):1836-1852.e11. View in: Pubmed

      • Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. 2021 05; 593(7860):580-585. View in: Pubmed

      • Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature. 2021 02; 590(7846):480-485. View in: Pubmed

      • Author Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2021 Feb; 590(7845):E31-E33. View in: Pubmed

      • No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians. Nat Metab. 2021 01; 3(1):107-117. View in: Pubmed

      • Mechanism of futile creatine cycling in thermogenesis. Am J Physiol Endocrinol Metab. 2020 11 01; 319(5):E947-E949. View in: Pubmed

      • Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 10 06; 32(4):665-675.e6. View in: Pubmed

      • Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo. Elife. 2020 08 11; 9. View in: Pubmed

      • Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. Nat Metab. 2020 Aug; 2(8):794. View in: Pubmed

      • CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 08 06; 182(3):563-577.e20. View in: Pubmed

      • A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity. Cell Chem Biol. 2020 09 17; 27(9):1130-1139.e4. View in: Pubmed

      • Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10789-10796. View in: Pubmed

      • Confounding issues in the "humanized" BAT of mice. Nat Metab. 2020; 2(4):303-304. View in: Pubmed

      • Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. Nat Metab. 2020 03; 2(3):278-289. View in: Pubmed

      • ?d T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 02; 578(7796):610-614. View in: Pubmed

      • Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nat Med. 2019 11; 25(11):1739-1747. View in: Pubmed

      • H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature. 2019 07; 571(7766):515-520. View in: Pubmed

      • An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metab. 2019 07 02; 30(1):190-200.e6. View in: Pubmed

      • Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 05; 569(7755):229-235. View in: Pubmed

      • Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nat Metab. 2019; 1(3):360-370. View in: Pubmed

      • Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. Dev Cell. 2019 01 28; 48(2):277-286.e6. View in: Pubmed

      • Irisin Mediates Effects on Bone and Fat via aV Integrin Receptors. Cell. 2018 12 13; 175(7):1756-1768.e17. View in: Pubmed

      • New Advances in Adaptive Thermogenesis: UCP1 and Beyond. Cell Metab. 2019 01 08; 29(1):27-37. View in: Pubmed

      • Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). View in: Pubmed

      • Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab. 2018 10 02; 28(4):631-643.e3. View in: Pubmed

      • Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6937-E6945. View in: Pubmed

      • Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):561-566. View in: Pubmed

      • Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity. Cell. 2017 Nov 02; 171(4):836-848.e13. View in: Pubmed

      • Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab. 2017 10 03; 26(4):693. View in: Pubmed

      • Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms. J Biol Chem. 2017 10 13; 292(41):16810-16816. View in: Pubmed

      • Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab. 2017 Oct 03; 26(4):660-671.e3. View in: Pubmed

      • UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7981-7986. View in: Pubmed

      • Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 04; 25(4):811-822.e4. View in: Pubmed

      • The Cancer Drug Dasatinib Increases PGC-1a in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice. Endocrinology. 2016 Nov; 157(11):4184-4191. View in: Pubmed

      • CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER. Trends Cancer. 2016 09; 2(9):461-463. View in: Pubmed

      • Attenuated PGC-1a Isoforms following Endurance Exercise with Blood Flow Restriction. Med Sci Sports Exerc. 2016 09; 48(9):1699-707. View in: Pubmed

      • Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 2016 08 15; 30(16):1822-36. View in: Pubmed

      • Cell biology of fat storage. Mol Biol Cell. 2016 08 15; 27(16):2523-7. View in: Pubmed

      • Cachexia and Brown Fat: A Burning Issue in Cancer. Trends Cancer. 2016 Sep; 2(9):461-463. View in: Pubmed

      • The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. 2016 Jul 14; 166(2):424-435. View in: Pubmed

      • CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. JCI Insight. 2016 Jun 16; 1(9). View in: Pubmed

      • Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 08 18; 536(7616):360. View in: Pubmed

      • Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 04 07; 532(7597):112-6. View in: Pubmed

      • A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 08; 23(3):454-66. View in: Pubmed

      • PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. Cell Metab. 2016 Feb 09; 23(2):315-23. View in: Pubmed

      • A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22; 163(3):643-55. View in: Pubmed

      • Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metab. 2015 Oct 06; 22(4):546-59. View in: Pubmed

      • Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab. 2015 Oct 06; 22(4):734-740. View in: Pubmed

      • Brown and Beige Fat: Molecular Parts of a Thermogenic Machine. Diabetes. 2015 Jul; 64(7):2346-51. View in: Pubmed

      • The future of brown adipose tissues in the treatment of type 2 diabetes. Diabetologia. 2015 Aug; 58(8):1704-7. View in: Pubmed

      • miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015 Apr 07; 21(4):584-95. View in: Pubmed

      • Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J Clin Endocrinol Metab. 2015 Apr; 100(4):1654-63. View in: Pubmed

      • Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPAR? effects. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):482-7. View in: Pubmed

      • An ERK/Cdk5 axis controls the diabetogenic actions of PPAR?. Nature. 2015 Jan 15; 517(7534):391-5. View in: Pubmed

      • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15756-61. View in: Pubmed

      • Thrap3 docks on phosphoserine 273 of PPAR? and controls diabetic gene programming. Genes Dev. 2014 Nov 01; 28(21):2361-9. View in: Pubmed

      • Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383. Diabetes. 2014 Sep; 63(9):e17. View in: Pubmed

      • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 2014 Sep 04; 513(7516):100-4. View in: Pubmed

      • Adipsin is an adipokine that improves ß cell function in diabetes. Cell. 2014 Jul 03; 158(1):41-53. View in: Pubmed

      • IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell. 2014 Jul 03; 158(1):69-83. View in: Pubmed

      • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014 Jun 05; 157(6):1279-1291. View in: Pubmed

      • A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014 May 06; 19(5):810-20. View in: Pubmed

      • Irisin ERKs the fat. Diabetes. 2014 Feb; 63(2):381-3. View in: Pubmed

      • Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16; 156(1-2):304-16. View in: Pubmed

      • What we talk about when we talk about fat. Cell. 2014 Jan 16; 156(1-2):20-44. View in: Pubmed

      • ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 07; 19(1):96-108. View in: Pubmed

      • Exercise induces hippocampal BDNF through a PGC-1a/FNDC5 pathway. Cell Metab. 2013 Nov 05; 18(5):649-59. View in: Pubmed

      • Time window expansion for HDX analysis of an intrinsically disordered protein. J Am Soc Mass Spectrom. 2013 Oct; 24(10):1584-92. View in: Pubmed

      • Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12480-5. View in: Pubmed

      • Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic disease. Diabetes. 2013 Jun; 62(6):1774-82. View in: Pubmed

      • The protein level of PGC-1a, a key metabolic regulator, is controlled by NADH-NQO1. Mol Cell Biol. 2013 Jul; 33(13):2603-13. View in: Pubmed

      • A conversation with Bruce Spiegelman. Interviewed by Ushma Neill. J Clin Invest. 2013 May; 123(5):1845-6. View in: Pubmed

      • PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013 Mar 18; 23(3):287-301. View in: Pubmed

      • Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 2013 Feb 01; 27(3):234-50. View in: Pubmed

      • A PGC-1a isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 07; 151(6):1319-31. View in: Pubmed

      • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. View in: Pubmed

      • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012 Jul 20; 150(2):366-76. View in: Pubmed

      • Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science. Skelet Muscle. 2012 Jun 07; 2(1):11. View in: Pubmed

      • Development of insulin resistance in mice lacking PGC-1a in adipose tissues. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9635-40. View in: Pubmed

      • Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 02; 15(5):778-86. View in: Pubmed

      • A novel therapeutic approach to treating obesity through modulation of TGFß signaling. Endocrinology. 2012 Jul; 153(7):3133-46. View in: Pubmed

      • A chemical screen probing the relationship between mitochondrial content and cell size. PLoS One. 2012; 7(3):e33755. View in: Pubmed

      • PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 07; 15(3):395-404. View in: Pubmed

      • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012 Feb 08; 15(2):230-9. View in: Pubmed

      • FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012 Feb 01; 26(3):271-81. View in: Pubmed

      • A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 11; 481(7382):463-8. View in: Pubmed

      • Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 07; 14(6):739-45. View in: Pubmed

      • Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011 11 24; 11(12):886-95. View in: Pubmed

      • QnAs with Bruce M. Spiegelman. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19121. View in: Pubmed

      • Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1a/ERR? complex. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18678-83. View in: Pubmed

      • Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation. Nature. 2011 Sep 04; 477(7365):477-81. View in: Pubmed

      • Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011 Aug; 152(8):2996-3004. View in: Pubmed

      • Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev. 2011 Jun 15; 25(12):1232-44. View in: Pubmed

      • PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell Metab. 2011 Apr 06; 13(4):351. View in: Pubmed

      • The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex. Cell Metab. 2011 Feb 02; 13(2):160-9. View in: Pubmed

      • C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010 Dec 23; 143(7):1072-83. View in: Pubmed

      • Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011 Jan; 121(1):96-105. View in: Pubmed

      • PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21866-71. View in: Pubmed

      • Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. Development. 2010 Oct; 137(20):3489-99. View in: Pubmed

      • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 2010 Jul 22; 466(7305):451-6. View in: Pubmed

      • NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):12317-22. View in: Pubmed

      • Transcriptional control of brown fat development. Cell Metab. 2010 Apr 07; 11(4):257-62. View in: Pubmed

      • Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010 Mar 25; 464(7288):619-23. View in: Pubmed

      • For a pragmatic approach to exercise studies. J Appl Physiol (1985). 2010 01; 108(1):223-3; author reply 226. View in: Pubmed

      • A rationale for SDS-PAGE of MHC isoforms as a gold standard for determining contractile phenotype. J Appl Physiol (1985). 2010 Jan; 108(1):222-2; author reply 226. View in: Pubmed

      • PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22510-5. View in: Pubmed

      • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20405-10. View in: Pubmed

      • Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27; 460(7259):1154-8. View in: Pubmed

      • PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. J Biol Chem. 2009 Jul 10; 284(28):18624-33. View in: Pubmed

      • Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 2009 Jul; 58(7):1499-508. View in: Pubmed

      • Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev. 2009 Apr 01; 23(7):788-97. View in: Pubmed

      • Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19926-31. View in: Pubmed

      • Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. Clin Cancer Res. 2008 Oct 15; 14(20):6478-86. View in: Pubmed

      • Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab. 2008 Sep; 8(3):249-56. View in: Pubmed

      • Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7. View in: Pubmed

      • PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21; 454(7207):961-7. View in: Pubmed

      • The role of exercise and PGC1alpha in inflammation and chronic disease. Nature. 2008 Jul 24; 454(7203):463-9. View in: Pubmed

      • A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis. J Biol Chem. 2008 Sep 05; 283(36):24290-4. View in: Pubmed

      • Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409. View in: Pubmed

      • Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4721-6. View in: Pubmed

      • HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008 Feb 21; 451(7181):1008-12. View in: Pubmed

      • Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985). 2008 May; 104(5):1304-12. View in: Pubmed

      • Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008; 77:289-312. View in: Pubmed

      • Cell Differentiation. Curr Opin Cell Biol. 2007 Dec; 19(6):603-604. View in: Pubmed

      • Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 2007 Nov; 117(11):3463-74. View in: Pubmed

      • Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem. 2007 Oct 12; 282(41):30014-21. View in: Pubmed

      • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12017-22. View in: Pubmed

      • Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul; 6(1):38-54. View in: Pubmed

      • Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell. 2007 May; 11(5):395-406. View in: Pubmed

      • A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7933-8. View in: Pubmed

      • PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev. 2007 Apr 01; 21(7):770-83. View in: Pubmed

      • The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007 Jan; 5(1):35-46. View in: Pubmed

      • Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Found Symp. 2007; 287:60-3; discussion 63-9. View in: Pubmed

      • Transcriptional control of energy homeostasis through the PGC1 coactivators. Novartis Found Symp. 2007; 286:3-6; discusssion 6-12, 162-3, 196-203. View in: Pubmed

      • Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006 Dec 14; 444(7121):847-53. View in: Pubmed

      • Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006 Dec; 4(6):453-64. View in: Pubmed

      • International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev. 2006 Dec; 58(4):726-41. View in: Pubmed

      • "The adipocyte: a multifunctional cell". Cell Metab. 2006 Dec; 4(6):425-7. View in: Pubmed

      • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006 Oct 20; 127(2):397-408. View in: Pubmed

      • PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16260-5. View in: Pubmed

      • Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 2006 Nov 01; 20(21):2996-3009. View in: Pubmed

      • Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006 Dec; 27(7):728-35. View in: Pubmed

      • Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14379-84. View in: Pubmed

      • Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):10086-91. View in: Pubmed

      • Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 2006 May; 3(5):333-41. View in: Pubmed

      • Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J Biol Chem. 2006 May 26; 281(21):14683-90. View in: Pubmed

      • The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005 Oct; 2(4):227-38. View in: Pubmed

      • Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005 Aug 26; 122(4):505-15. View in: Pubmed

      • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005 Aug 12; 309(5737):1074-8. View in: Pubmed

      • Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005 Jun; 1(6):361-70. View in: Pubmed

      • Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. J Med Genet. 2005 May; 42(5):402-7. View in: Pubmed

      • Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr; 1(4):259-71. View in: Pubmed

      • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 03; 434(7029):113-8. View in: Pubmed

      • Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 01; 19(3):362-75. View in: Pubmed

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      Dana-Farber Cancer Institute

      450 Brookline Avenue CLS 11-145 Boston, MA 02215
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue CLS 11-145 Boston, MA 02215
      Get Direction
      42.3374, -71.1082