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The goals of my research are to: 1) identify exciting new treatments for brain cancer in the laboratory using animal models; 2) understand how these treatment approaches are working to fight cancer cells in order to optimize their effectiveness; and 3) move these promising approaches as quickly as possible to the clinic via clinical trials to help brain cancer patients. My laboratory focuses primarily on innovative and cutting-edge immunotherapies as single agents and in rationally designed, combinational approaches that include a wide array of additional therapies. We utilize a variety of brain tumor models that are grown intracranially and treatments that are applied systemically and/or locally. We have access to state-of-the-art imaging systems including MRI, PET scans and bioluminescence to help us evaluate the "success" of our treatments in our animal models. We collaborate with several outstanding cancer immunology scientists who can help us comprehensively evaluate mechanisms of action of our therapies by applying advanced techniques to evaluate harvested intracranial tumors, draining lymph nodes, other lymphatic organs and peripheral blood. Results of our work continue to drive new clinical trials evaluating promising approaches for brain cancer patients. My research effort also extends into the clinic and specifically includes designing and implementing clinical trials to effectively evaluate promising new therapies as quickly as possible for our patients.
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