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Ursula A. Matulonis, MD

Medical Oncology

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  • Chief, Division of Gynecologic Oncology
  • Brock-Wilson Family Chair
  • Institute Physician
  • Professor of Medicine, Harvard Medical School


Clinical Interests

  • Gynecologic malignancies
  • New therapies for gynecologic cancers

Contact Information

  • Appointments617-632-2175
  • Office Phone Number617-632-2334
  • Fax617-632-3479


Ursula A. Matulonis, MD is Chief, Division of Gynecologic Oncology at Dana-Farber Cancer Institute and Professor of Medicine at Harvard Medical School. Her research focuses on targeted therapies for gynecologic malignancies, with a specific interest in the genetic changes in ovarian cancer and how that can lead to rationale targeted drug selection. Dr. Matulonis is the Principal Investigator of several clinical trials and translational studies for ovarian cancer. Dr. Matulonis is a Co-PI on an ovarian cancer SPORE project entitled “Identification of Oncogenic Mutations in Ovarian Cancer,” and a Co-PI on the project “Genetic relationships between breast and ovarian cancer” that is funded by the Breast Cancer Research Foundation. She is also a past recipient of a DF/HCC Ovarian Cancer SPORE Developmental Grant entitled “Genetic Fingerprinting of Ovarian Cancer.”

Dr. Matulonis serves on the National Comprehensive Cancer Network Ovarian Cancer Recommendation and Guideline Committee for both ovarian cancer and for the treatment of anemia, the Gynecologic Oncology Group Quality of Life Committee, a member of The Cancer Genome Atlas Project (TCGA) Endometrial Analysis Working Group, and is Medical Director and Board Member for the non-profit organization Ovations for the Cure. She is a recipient of the Dennis Thompson Compassionate Care Scholar award, the Lee Nadler “Extra Mile” Award, and was named one of Boston’s Best Physicians in Medical Oncology by Boston Magazine numerous times. She serves on the editorial board of the Journal of Clinical Oncology.

After receiving her MD from Albany Medical College, she completed an internship and residency at the University of Pittsburgh, followed by a medical oncology fellowship at Dana-Farber.

Board Certification:

  • Internal Medicine, 2000
  • Medical Oncology, 2003


  • Dana-Farber Cancer Institute, Medical Oncology


  • University of Pittsburgh, Internal Medicine

Medical School:

  • Albany Medical College

Recent Awards:

  • Partners in Excellence Award, Partners Health Care 2010
  • Lee Nadler "Extra Mile" Award 2009
  • "Boston Magazine" Best Doctors 2009
  • Partners in Excellence Award, Partners Health Care 2000
  • Dennis Thompson Compassionate Care Scholar, Brigham and Women's Hospital 2000


Clinical Trials in Gynecologic Malignancies

The Medical Gynecologic Oncology Program serves as the infrastructure for clinical and translational research at Dana-Farber Cancer Institute. Our research involves testing novel drugs and biologics in newly diagnosed as well as recurrent gynecologic tumors: ovarian, endometrial, cervical, vaginal, and vulvar cancers. A list of ongoing clinical trials is available via our website. Our integrated team of medical oncologists, gynecologic oncology surgeons, radiation oncologists, gynecologic oncology pathologists, clinical research team, and basic science researchers is immersed in a number of translational projects. Examples of ongoing projects in 2010 include the expression profiling and genotyping of ovarian cancer, the study of circulating tumor cells in ovarian cancer, investigation of HER3 expression and signalling and therapeutic potential of HER3, and the study of the PI3 kinase pathway in endometrial cancer.


Dana-Farber Cancer Institute
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